Luis Suarez scored a penalty in each half to give Inter Miami a 2-1 win over Tigres UANL on Wednesday, stepping up to fill the void after Lionel Messi was ruled out of the Leagues Cup quarter-final clash.
Messi, who has battled a "minor" muscle injury since a Leagues Cup group match on August 2, returned Saturday after a two-week absence, scoring a goal after coming on as a substitute in a 3-1 win over the Los Angeles Galaxy.
However, the 38-year-old World Cup winner was ruled out against Tigres as Inter advanced in the cross-border club competition for teams from Major League Soccer and Mexico's Liga-MX.
"We rely on how Leo feels and it wasn't the best," Inter assistant coach Javier Morales said. "We preferred not to take risks, not to go backward in his recovery."
In a duel that produced few scoring chances, veteran Uruguay striker Suarez was the difference as Inter kept alive their hopes of regaining the title they won in 2023, during Messi's first season in MLS.
Things swung Miami's way in the 20th minute when Javier Aquino slid to intercept a cross and the ball hit his left arm in the area.
The referee awarded the penalty and the 38-year-old Suarez converted.
Tempers flared, with Suarez moving to calm things down after Miami teammate Rodrigo De Paul and Uruguayan compatriot Fernando Gorriaran exchanged words.
Inter coach Javier Mascherano was sent off at half time, receiving a red card for heated protestations to officials after injury time dragged on past what had been indicated.
Mascherano watched from the stands when Tigres grabbed their equalizer in the 67th minute, Angel Correa slipping between two defenders and beating Miami keeper Oscar Ustari.
Another handball by Aquino in the 87th minute, confirmed by VAR, gave Miami another penalty and Suarez converted again, this time going left as goalkeeper Nahuel Guzman dived in the opposite direction.
Miami booked a semi-final clash on August 27 with Florida rivals Orlando City, who beat Liga MX champions Toluca FC 6-5 on penalties after the teams played to a scoreless draw in Carson, California.
- MLS sweep -
Seattle Sounders and LA Galaxy completed the quarter-final sweep for MLS clubs, Seattle beating Club Puebla 4-3 on penalties after the teams drew 0-0 and the Galaxy topping Pachuca 2-1.
Goalkeeper Pedro Gallese was the hero for Orlando against Toluca, saving two penalties in the shootout and scoring the decisive penalty himself.
Sounders keeper Andrew Thomas made two huge saves in the shootout in Seattle, stopping shots from Ricardo Marin and Nicolas Diaz to help the Sounders advance despite the 76th-minute sending off of Danny Musovski.
He was shown a yellow card for a foul on Nicolas Diaz and then a red for a furious protest in which he bumped the referee.
LA Galaxy, enduring a tough season after lifting the MLS Cup last year, will host Seattle next week after a victory in which Marco Reus played a key role.
The German veteran forced an own goal from Alonso Aceves in the 27th minute, receiving a short corner kick and firing the ball across the face of goal where Aceves's attempt to clear it instead sent the ball into his own net.
Reus made it 2-0 when he pounced on a loose ball in the 37th minute and slammed it home.
Brazilian Alemao pulled a goal back for Pachuca in second-half stoppage time.
Both finalists emerging from next week's semis and the third-place match winner will qualify for the CONCACAF Champions Cup, with the Leagues Cup champion securing direct entry to the Champions Cup round of 16.